New in vivo test reveals age gain by 2 years in just 1 month
Mid 2011, a new proof of the efficiency of Matrixyl® 3000, the famous peptide blend, was made available. This time, it was its ability to help repair the UV damage-prone papillary dermis that was demonstrated.
The papillary dermis, located just under the dermis/epidermis junction (DEJ), is more fragile than the reticular dermis and is intensely affected by photo aging. Papillary fibroblasts are fundamental to promote epidermal morphogenesis and wound healing that is why papillary dermis repair delivers visible anti-wrinkle benefits.
In vivo studies have revealed the positive matrix reinforcing effect of Matrixyl® 3000 by measuring the SLEB density (Subepidermal Low Echogenic Band that corresponds to the papillary dermis). A significant improvement corresponding to a gain in age of 1.8 years is visible in just one month, and confirmed after 2 months: the photo-induced aging is then delayed by 5.5 years.
Another analysis of the papillary dermis by confocal laser microscopy has shown that Matrixyl® 3000 helps reduce the fibre fragmentation and notably supports the reconstruction of the papillary dermal fibre network.
2013: New study confirms previous findings
A complementary approach is confirming Matrixyl® 3000’s repairing effect of the cutaneous damages of aging. Now it is its ability to reverse chronological aging that has been demonstrated with both in vitro and ex vivo studies.
First, Matrixyl® 3000 has been shown to regulate the expression of well-known (SA ß-galactosidase) and recently discovered (progerin) markers of senescence. Progerin is an altered form of the lamin A protein (lamins are key proteins in the skin’s regenerative process). With age, progerin's expression rises, as well as the skin tissue disorganisation. Matrixyl® 3000 does not only reduce the SA ß-galactosidase activity, but it also reduces the progerin's expression while preserving the expression of the normal form lamin A.
Then, immunohistochemistry analysis of skin sections (ex vivo study) has proved that Matrixyl® 3000 significantly stimulates synthesis of Collagen-I, -IV, -VII, -XVII and Nidogen-I proteins. While these proteins of the dermis and dermal-epidermal junction usually decrease with age, Matrixyl® 3000 rejuvenates the dermal structure and tends to make aging skin behave like young skin.
Matrixyl® 3000 restores skin’s metabolism of youth. These innovative tests and claims give you one more reason to claim “Matrixyl® inside” on your products.
- REPAIR OF THE PAPILLARY DERMIS
28 female volunteers aged from 51 to 72 years, mean age 59. Twice daily application of a cream containing 3% of Matrixyl®3000 for 2 months to one half of the face and the forearm (inner and UV-exposed outer forearm) against placebo.
- ANALYSIS OF THE FIBRE NETWORK
Measurements of the fibre defragmentation by confocal laser microscopy (Vivascope) on the face, next to the external eye corner.Matrixyl®3000 helps reduce the fiber fragmentation and notably supports the reconstruction of the papillary dermal fiber network.
- ANTI-WRINKLE EFFICACY, SKIN TONE AND ELASTICITY
23 female volunteers aged from 42 to 67 years / Twice daily application on one half of the face of a cream containing 3% of Matrixyl®3000 against placebo, for 2 months. Assessment of the anti-wrinkle efficacy by profilometry, cutometry and photography compared to T0.The repairing effect of Matrixyl®3000 promotes the visible quality of the skin by decreasing the appearance of wrinkles and improving tone and elasticity.
Non-warranty: The information in this publication is believed to be accurate and is given in good faith, but no representation or warranty as to its completeness or accuracy is made. Suggestions for uses or applications are only opinions. Users are responsible for determining the suitability of these products for their own particular purpose. No representation or warranty, expressed or implied, is made with respect to information or products including, without limitation, warranties of merchantability, fitness for a particular purpose, non-infringement of any third party patent or other intellectual property rights including, without limit, copyright, trademark and designs. Any trademarks identified herein, unless otherwise noted, are trademarks ©2015 Sederma
[ITEMPRICE]
Lead Times 1-3 Business Days